Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.

doi:10.1242/jcs.111.8.1117

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Article

Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.

Journal of cell science - 1 Apr 1998

Wennerberg K, Fässler R, Wärmegård B, Johansson S

Abstract excerpt

To investigate the role of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A, point mutated variants of the protein were stably expressed in the beta1-deficient cell line GD25. Mutants T777A, Y783F, S785A, and Y795F were fully active in promoting cell adhesion, de n...

Topics

Amino Acid Sequence
Animals
Cell Adhesion
Cell Adhesion Molecules
Cell Line
Chickens
Cytoplasm
DNA Mutational Analysis
Extracellular Matrix Proteins
Fibronectins
Flow Cytometry
Focal Adhesion Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Focal Adhesion Protein-Tyrosine Kinases

Humans

Integrin beta1

Mice

Molecular Sequence Data

Mutagenesis, Site-Directed

Source

Open in PubMed

Identifiers

PMID: 9512507
DOI: 10.1242/jcs.111.8.1117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9512507-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.PMID 9512507Read ↗

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