Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.

Journal of cell science - 1 Apr 1998

Wennerberg K, Fässler R, Wärmegård B, Johansson S

Abstract excerpt

To investigate the role of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A, point mutated variants of the protein were stably expressed in the beta1-deficient cell line GD25. Mutants T777A, Y783F, S785A, and Y795F were fully active in promoting cell adhesion, de novo formation of focal contacts, formation of fibronectin fibrils, and activation of focal adhesion kinase. Thus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chickens

Share to DNA Mutational Analysis

Share to Flow Cytometry

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Source

Identifiers

PMID: 9512507
DOI: 10.1242/jcs.111.8.1117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.PMID 9512507Read ↗

Threonine 788 in integrin subunit beta1 regulates integrin activation.Semantic proximity Read ↗

The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation.Semantic proximity Read ↗

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.Semantic proximity Read ↗

Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells.Semantic proximity Read ↗

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.Semantic proximity Read ↗

Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.Semantic proximity Read ↗

Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization.Semantic proximity Read ↗

Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways.Semantic proximity Read ↗

Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation.Semantic proximity Read ↗

Cytoplasmic domain mutants of beta1 integrin, expressed in beta 1-knockout lymphoma cells, have distinct effects on adhesion, invasion and metastasis.Semantic proximity Read ↗

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.Semantic proximity Read ↗

The role of phosphorylation in modulating beta 1 integrin localization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.