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Article

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

The Journal of biological chemistry - 16 May 2003

Pankov Roumen, Cukierman Edna, Clark Katherine, Matsumoto Kazue, Hahn Cornelia, Poulin Benoit, Yamada Kenneth M

Abstract excerpt

Integrin transmembrane receptors generate multiple signals, but how they mediate specific signaling is not clear. Here we test the hypothesis that particular sequences along the beta(1) integrin cytoplasmic domain may exist that are intimately related to specific integrin-mediated signaling pathways. Using systematic alanine mutagenesis of amino acids conserved between different beta integrin cytoplasmic domains,...

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PMID: 12637511
DOI: 10.1074/jbc.M300879200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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