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Article

Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion.

The Journal of biological chemistry - 1 Jun 2001

Xie B, Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y

Abstract excerpt

Recent studies suggest that focal adhesion kinase (FAK) is important for cell migration. We now suggest a mechanism by which FAK activates the signal transducer and activator of transcription (STAT) pathway, regulating cell adhesion and migration. In particular, we observe that FAK is capable of activating Stat1, but not Stat3. Co-immunoprecipitation and in vitro binding assays demonstrate that Stat1 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11278462
DOI: 10.1074/jbc.M009063200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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