Article
Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.
The Journal of cell biology - 21 Nov 2005
Fagerholm Susanna C, Hilden Tiina J, Nurmi Susanna M, Gahmberg Carl G
Abstract excerpt
Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this process have remained incompletely understood. In this study, we report that the phosphorylation of each cytoplasmic domain of the leukocyte function-associated...
Topics
- 14-3-3 Proteins
- Amino Acid Sequence
- Animals
- Antigens, CD
- COS Cells
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- Cell Line, Tumor
- Chemokines
- Chlorocebus aethiops
- Chromatography, Affinity
- Cytoplasm
- Cytoskeleton