Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.

The Journal of cell biology - 21 Nov 2005

Fagerholm Susanna C, Hilden Tiina J, Nurmi Susanna M, Gahmberg Carl G

Abstract excerpt

Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this process have remained incompletely understood. In this study, we report that the phosphorylation of each cytoplasmic domain of the leukocyte function-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Chemokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatography, Affinity

Share to Cytoskeleton

Share to Integrins

Share to Intercellular Adhesion Molecule-1

Share to Lymphocyte Function-Associated Antigen-1

Source

Open in PubMed Open full text

Identifiers

PMID: 16301335
DOI: 10.1083/jcb.200504016
PMCID: PMC2171568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.PMID 16301335Read ↗

alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation.Semantic proximity Read ↗

The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.Semantic proximity Read ↗

Integrin signalling and function in immune cellsSemantic proximity Read ↗

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cellsSemantic proximity Read ↗

LFA-1 in T Cell Migration and DifferentiationSemantic proximity Read ↗

β2 integrin activation and signal transduction in leukocyte recruitmentSemantic proximity Read ↗

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin‐linked kinase, ILK1Semantic proximity Read ↗

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.Semantic proximity Read ↗

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.Semantic proximity Read ↗

Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

Integrin signaling: it's where the action isSemantic proximity Read ↗

Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.