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Article

Direct haplotyping of kilobase-size DNA using carbon nanotube probes.

Nature biotechnology - 1 Jul 2000

Woolley A T, Guillemette C, Li Cheung C, Housman D E, Lieber C M

Abstract excerpt

We have implemented a method for multiplexed detection of polymorphic sites and direct determination of haplotypes in 10-kilobase-size DNA fragments using single-walled carbon nanotube (SWNT) atomic force microscopy (AFM) probes. Labeled oligonucleotides are hybridized specifically to complementary target sequences in template DNA, and the positions of the tagged sequences are detected by direct SWNT tip imaging....

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Identifiers

PMID: 10888845
DOI: 10.1038/77760

Genes

AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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