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Article

Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry.

Genomics - 1 May 2004

Kim Sobin, Ulz Michael E, Nguyen Tuan, Li Chi-Ming, Sato Takaaki, Tycko Benjamin, Ju Jingyue

Abstract excerpt

A mass spectrometry (MS) based multiplex genotyping method using solid phase capturable (SPC) dideoxynucleotides and single base extension (SBE), named the SPC-SBE, has been developed for mutation detection. We report here the simultaneous genotyping of 30 potential point mutation sites in exons 5, 7, and 8 of the human p53 gene in one tube using the SPC-SBE method. The 30 mutation sites, including the most...

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PMID: 15081121
DOI: 10.1016/j.ygeno.2003.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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