Article
Direct determination of haplotypes from single DNA molecules.
Nature methods - 1 Mar 2009
Xiao Ming, Wan Eunice, Chu Catherine, Hsueh Wen-Chi, Cao Yang, Kwok Pui-Yan
Abstract excerpt
Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately determining the haplotypes consisting of up to 16 single-nucleotide polymorphisms in genomic regions up to 50 kilobases.
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