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Article

Determination of haplotypes from single DNA molecules: a method for single-molecule barcoding.

Human mutation - 1 Sept 2007

Xiao Ming, Gordon Matthew P, Phong Angie, Ha Connie, Chan Ting-Fung, Cai Dongmei, Selvin Paul R, Kwok Pui-Yan

Abstract excerpt

Determining the haplotypes in a diploid individual is a major technical challenge in genetic studies of human complex traits. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual DNA molecules simultaneously. DNA fragments amplified by long-range PCR were labeled with fluorescent dyes at each polymorphic site using a modified gap-filled padlock probe...

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Identifiers

PMID: 17443670
DOI: 10.1002/humu.20528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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