Article
Highly specific SNP detection using 2D graphene electronics and DNA strand displacement.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2016
Hwang Michael T, Landon Preston B, Lee Joon, Choi Duyoung, Mo Alexander H, Glinsky Gennadi, Lal Ratnesh
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) in a gene sequence are markers for a variety of human diseases. Detection of SNPs with high specificity and sensitivity is essential for effective practical implementation of personalized medicine. Current DNA sequencing, including SNP detection, primarily uses enzyme-based methods or fluorophore-labeled assays that are time-consuming, need laboratory-scale settings, and are...
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