Article
DNA origami-based shape IDs for single-molecule nanomechanical genotyping.
Nature communications - 6 Apr 2017
Zhang Honglu, Chao Jie, Pan Dun, Liu Huajie, Qiang Yu, Liu Ke, Cui Chengjun, Chen Jianhua, Huang Qing, Hu Jun, Wang Lianhui, Huang Wei, Shi Yongyong, Fan Chunhai
Abstract excerpt
Variations on DNA sequences profoundly affect how we develop diseases and respond to pathogens and drugs. Atomic force microscopy (AFM) provides a nanomechanical imaging approach for genetic analysis with nanometre resolution. However, unlike fluorescence imaging that has wavelength-specific fluorophores, the lack of shape-specific labels largely hampers widespread applications of AFM imaging. Here we report the...
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