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Article

Single-Molecule Nanomechanical Genotyping with DNA Origami-Based Shape IDs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Li Qian, Chao Jie, Zhang Honglu, Fan Chunhai

Abstract excerpt

Atomic force microscopy (AFM)-based nanomechanical imaging provides a sub-10-nm-resolution approach for imaging biomolecules under ambient conditions. Here we describe how to generate a set of DNA origami-based shape IDs (triangular and cross shape, with and without streptavidin) to site-specifically label target genomic DNA sequences containing two single-nucleotide polymorphisms (SNPs). Adjacent labeling sites...

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PMID: 37166716
DOI: 10.1007/978-1-0716-3028-0_9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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