Article
Analysis of the TCRBV repertoire of T cells in normal, human skin: evidence for a restricted diversity.
The Journal of investigative dermatology - 1 Jul 2000
Menssen A, Vollmer S, Trommler P, Sander C, Prinz J C
Abstract excerpt
Alpha beta T cells constitute an important component in the first line of immunologic defense in human skin. In order to determine the local selection forces driving T cell diversity, we studied the T cell receptor repertoire in normal human skin and compared it with that of matched blood samples. Using semiquantitative reverse transcription-polymerase chain reaction the expression of T cell receptor beta-chain V...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Female
- Gene Expression Profiling
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genes, T-Cell Receptor
- Genetic Variation
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Receptors, Antigen, T-Cell, alpha-beta
- Skin