Article
The human T-cell receptor beta-chain repertoire: longitudinal fluctuations and assessment in MHC matched populations.
Immunogenetics - 1 Jan 1993
Usuku K, Joshi N, Hatem C J, Alper C A, Schoenfeld D A, Hauser S L
Abstract excerpt
The influence of the environment and of the major histocompatibility complex (MHC) in shaping the human T-cell receptor beta-chain variable region (TCRBV) repertoire has not been systematically studied. Here, expression of TCRBV gene families was estimated by a sensitive polymerase chain reaction...
Topics
- Base Sequence
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- DNA, Single-Stranded
- Gene Expression
- Genetic Variation
- Humans
- Major Histocompatibility Complex
- Molecular Sequence Data
- Polymerase Chain Reaction
- RNA, Messenger
- Receptors, Antigen, T-Cell, alpha-beta
- Sensitivity and Specificity
- T-Lymphocyte Subsets