Article
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Chen F, Capecchi M R
Abstract excerpt
Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogou...
Topics
- Animals
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genotype
- In Situ Hybridization
- Mammary Glands, Animal
- Mice
- Mice, Knockout
- Mutation
- Pregnancy
- RNA, Messenger