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Article

Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999

Chen F, Capecchi M R

Abstract excerpt

Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in...

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Identifiers

PMID: 9892669
DOI: 10.1073/pnas.96.2.541
PMCID: PMC15172

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