Article
Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000
Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock S M, Uysal K T, Cinti S, Carruba M O, Hotamisligil G S
Abstract excerpt
Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor alpha (TNF-alpha) in obesity is involved in functional brown fat atrophy, we have studied genetically obese (ob/ob) mice with targeted null mutations in the genes encoding the two TNF receptors. The absence of both TNF receptors or p55 receptor alone resulted in a...
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