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Article

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

Nature - 9 Oct 1997

Uysal K T, Wiesbrock S M, Marino M W, Hotamisligil G S

Abstract excerpt

Obesity is highly associated with insulin resistance and is the biggest risk factor for non-insulin-dependent diabetes mellitus. The molecular basis of this common syndrome, however, is poorly understood. It has been suggested that tumour necrosis factor (TNF)-alpha is a candidate mediator of insulin resistance in obesity, as it is overexpressed in the adipose tissues of rodents and humans and it blocks the...

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PMID: 9335502
DOI: 10.1038/39335

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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