Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.

doi:10.1210/endo.139.12.6337

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Article

Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.

Endocrinology - 1 Dec 1998

Uysal K T, Wiesbrock S M, Hotamisligil G S

Abstract excerpt

Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance and noninsulin-dependent diabetes mellitus, the molecular mechanisms underlying these disorders are not clearly understood. Tumor necrosis factor-alpha (TNF-alpha...

Topics

Animals
Body Composition
Glucose
Glucose Tolerance Test
Homeostasis
Insulin Resistance
Lipids
Mice
Mutation
Obesity
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha

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