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Article

Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning.

Scientific reports - 20 Jul 2020

Choi Eun Wha, Lee Minjae, Song Ji Woo, Kim Kyeongdae, Lee Jungmin, Yang Jehoon, Lee Seo Hyun, Kim Il Yong, Choi Jae-Hoon, Seong Je Kyung

Abstract excerpt

Brown adipose tissue generates heat via the mitochondrial uncoupling protein UCP1 to protect against obesity and hypothermia. Fas mutant MRL/lpr mice exhibit a significantly leaner phenotype compared to wild type MRL/MpJ mice. In this study, we evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. Furthermore, we compared beige...

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Identifiers

PMID: 32686763
DOI: 10.1038/s41598-020-68971-7
PMCID: PMC7371740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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