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Article

Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals.

Obesity (Silver Spring, Md.) - 1 Oct 2009

Lautenbach Anne, Wrann Christiane D, Jacobs Roland, Müller Guenter, Brabant Georg, Nave Heike

Abstract excerpt

In diet-induced obese rats, leptin-mediated natural killer (NK) cell activation has been demonstrated to be impaired by abrogated intracellular JAK2-STAT3 signaling. The contribution of the obese microenvironment to this NK cell dysfunction and its reversibility remains elusive. In this study, the functions of NK cells from diet-induced obese rats after adoptive transfer into lean littermates were investigated...

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Source

Identifiers

PMID: 19444229
DOI: 10.1038/oby.2009.140

Genes

JAK2
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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