Article
Characterization of a human alpha1-antitrypsin variant that is as stable as ovalbumin.
The Journal of biological chemistry - 30 Jan 1998
Lee K N, Im H, Kang S W, Yu M H
Abstract excerpt
The metastability of inhibitory serpins (serine proteinase inhibitors) is thought to play a key role in the facile conformational switch and the insertion of the reactive center loop into the central beta-sheet, A-sheet, during the formation of a stable complex between a serpin and its target pro...
Topics
- Humans
- Models, Chemical
- Models, Molecular
- Mutation
- Ovalbumin
- Pancreatic Elastase
- Protein Conformation
- Protein Denaturation
- Protein Folding
- alpha 1-Antitrypsin