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Article

Cellular folding pathway of a metastable serpin.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2016

Chandrasekhar Kshama, Ke Haiping, Wang Ning, Goodwin Theresa, Gierasch Lila M, Gershenson Anne, Hebert Daniel N

Abstract excerpt

Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically important functions. However, how metastable proteins fold to these higher free energy states in...

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PMID: 27222580
DOI: 10.1073/pnas.1603386113
PMCID: PMC4988602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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