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Article

Probing the folding pathway of a consensus serpin using single tryptophan mutants.

Scientific reports - 1 Feb 2018

Yang Li, Irving James A, Dai Weiwen, Aguilar Marie-Isabel, Bottomley Stephen P

Abstract excerpt

Conserpin is an engineered protein that represents the consensus of a sequence alignment of eukaryotic serpins: protease inhibitors typified by a metastable native state and a structurally well-conserved scaffold. Previously, this protein has been found to adopt a native inhibitory conformation, possess an atypical reversible folding pathway and exhibit pronounced resistance to inactivation. Here we have designed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29391487
DOI: 10.1038/s41598-018-19567-9
PMCID: PMC5794792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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