Article
A protein family under 'stress' - serpin stability, folding and misfolding.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2005
Devlin Glyn L, Bottomley Stephen P
Abstract excerpt
The native fold of inhibitory serpins (serpin proteinase inhibitors) is metastable and therefore does not represent the most stable conformation that the primary sequence encodes for. The most stable form is adopted when the reactive centre loop (RCL) inserts, as the fourth strand, into the A b -sheet. Currently a serpin can adopt at least four more stable conformations, termed the cleaved, delta, latent and...
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