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Article

Local and global effects of a cavity filling mutation in a metastable serpin.

Biochemistry - 1 Sept 2009

Sengupta Tanusree, Tsutsui Yuko, Wintrode Patrick L

Abstract excerpt

The serpins are an unusual class of protease inhibitors which fold to a metastable form and subsequently undergo a massive conformational change to a stable form when they inhibit their target proteases. The driving force for this conformational change has been extensively investigated by site di...

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Identifiers

PMID: 19624115
DOI: 10.1021/bi900342d
PMCID: PMC2746415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19624115-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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