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Article

Role of Lys335 in the metastability and function of inhibitory serpins.

Protein science : a publication of the Protein Society - 1 May 2000

Im H, Yu M H

Abstract excerpt

The native form of inhibitory serpins (serine protease inhibitors) is not in the thermodynamically most stable state but in a metastable state, which is critical to inhibitory functions. To understand structural basis and functional roles of the native metastability of inhibitory serpins, we have been characterizing stabilizing mutations of human alpha1-antitrypsin, a prototype inhibitory serpin. One of the sites...

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Identifiers

PMID: 10850803
DOI: 10.1110/ps.9.5.934
PMCID: PMC2144637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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