Article
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis.
Cell - 20 Sept 2002
Kang David E, Soriano Salvador, Xia Xuefeng, Eberhart Charles G, De Strooper Bart, Zheng Hui, Koo Edward H
Abstract excerpt
The Alzheimer's disease-linked gene presenilin 1 (PS1) is required for intramembrane proteolysis of APP and Notch. In addition, recent observations strongly implicate PS1 as a negative regulator of the Wnt/beta-catenin signaling pathway, although the mechanism underlying this activity is unknown. Here, we show that presenilin functions as a scaffold that rapidly couples beta-catenin phosphorylation through two...
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