Article
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.
Genes & development - 15 Jun 1996
Yost C, Torres M, Miller J R, Huang E, Kimelman D, Moon R T
Abstract excerpt
The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus. Although genetic evidence from Drosophila indicates that Xgsk-3 is upstream of beta-catenin, direct interactions between these proteins have not...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Nucleus
- Cytoskeletal Proteins
- Embryo, Nonmammalian
- Embryonic Development
- Embryonic Induction
- Gene Expression Regulation, Developmental
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Molecular Sequence Data
- Morphogenesis