Article
Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK.
The Journal of biological chemistry - 20 Jun 2008
Yamaguchi Yukihiro, Larkin Dennis, Lara-Lemus Roberto, Ramos-Castañeda Jose, Liu Ming, Arvan Peter
Abstract excerpt
The activity of PERK, an endoplasmic reticulum (ER) transmembrane protein kinase, assists in an ER stress response designed to inhibit general protein synthesis while allowing upregulated synthesis of selective proteins such as the ATF4 transcription factor. PERK null mice exhibit phenotypes that especially affect secretory cell types. Although embryonic fibroblasts from these mice are difficult to transfect with...
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