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Article

FAD-linked presenilin-1 mutants impede translation regulation under ER stress.

Biochemical and biophysical research communications - 16 Aug 2002

Yasuda Yuka, Kudo Takashi, Katayama Taiichi, Imaizumi Kazunori, Yatera Misako, Okochi Masayasu, Yamamori Hidenaga, Matsumoto Naohiko, Kida Takayuki, Fukumori Akio, Okumura Masayo, Tohyama Masaya, Takeda Masatoshi

Abstract excerpt

FAD mutations in presenilin-1 (PS1) cause attenuation of the induction of the endoplasmic reticulum (ER)-resident chaperone GRP78/BiP under ER stress, due to disturbed function of IRE1, the sensor for accumulation of unfolded protein in the ER lumen. PERK, an ER-resident transmembrane protein kinase, is also a sensor for the unfolded protein response (UPR), causing phosphorylation of eukaryotic initiation factor...

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Identifiers

PMID: 12163019
DOI: 10.1016/s0006-291x(02)00859-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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