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Article

Identification of the UV-responsive sequence in the human tissue plasminogen activator gene.

Bioscience, biotechnology, and biochemistry - 1 May 2000

Fujiwara J, Fujii M, Shimoda M, Ayusawa D

Abstract excerpt

Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.

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Identifiers

PMID: 10879489
DOI: 10.1271/bbb.64.1084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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