Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.

doi:10.1002/j.1460-2075.1992.tb05563.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.

The EMBO journal - 1 Dec 1992

Bauknecht T, Angel P, Royer H D, zur Hausen H

Abstract excerpt

The human papillomavirus type 18 (HPV-18) promoter contains a TPA responsive element (TRE) which confers TPA responsiveness on a heterologous promoter. In the context of the HPV-18 promoter, however, this AP-1 site is inactive. We have identified a negative regulatory domain in the HPV-18 promote...

Topics

Base Sequence
Binding Sites
Cells, Cultured
Chloramphenicol O-Acetyltransferase
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Erythroid-Specific DNA-Binding Factors
Genes, Viral
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Papillomaviridae

Polymerase Chain Reaction

Promoter Regions, Genetic

Proto-Oncogene Proteins c-jun

Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 1330541
DOI: 10.1002/j.1460-2075.1992.tb05563.x
PMCID: PMC557037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1330541-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.PMID 1330541Read ↗

A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoterSemantic proximity Read ↗

YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity.Semantic proximity Read ↗

Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis ElementsSemantic proximity Read ↗

The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS CellsSemantic proximity Read ↗

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.Semantic proximity Read ↗

Identification of novel cellular transcription factors that regulate early promoters of human papillomavirus types 18 and 16.Semantic proximity Read ↗

A single element mediates glucocorticoid hormone response of HPV18 with no functional interactions with AP1 or hbrm.Semantic proximity Read ↗

Prevalence of deletions of YY1‐binding sites in episomal HPV 16 DNA from cervical cancersSemantic proximity Read ↗

Control of HPV 18 DNA replication by cellular and viral transcription factors.Semantic proximity Read ↗

Genetic variation at a Yin-Yang 1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18INK4C transcript in lupus-prone mice.Semantic proximity Read ↗

Regulation of human papillomavirus transcription by the differentiation-dependent epithelial factor Epoc-1/skn-1a.Semantic proximity Read ↗

Yin Yang 1 Negatively Regulates the Differentiation-Specific E1 Promoter of Human Papillomavirus Type 6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.