Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.

doi:10.1016/0167-4889(95)00050-3

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Article

Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.

Biochimica et biophysica acta - 20 Jul 1995

Lengyel E, Klostergaard J, Boyd D

Abstract excerpt

The urokinase-type plasminogen activator plays a central role in tissue remodeling by controlling the synthesis of the extracellular matrix-degrading plasmin. Urokinase expression is transcriptionally regulated by a variety of cytokines including TNF-alpha. The present study was undertaken to ide...

Topics

Base Sequence
Binding Sites
Chloramphenicol O-Acetyltransferase
DNA
Enzyme Induction
Genes, Reporter
Humans
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
RNA, Messenger
Transcription Factor AP-1
Transcription Factors
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha
Urokinase-Type Plasminogen Activator

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PMID: 7626664
DOI: 10.1016/0167-4889(95)00050-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7626664-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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