Transcriptional regulation of the tissue‐type plasminogen‐activator gene in human endothelial cells : identification of nuclear factors that recognise functional elements in the tissue‐type plasminogen‐activator gene promoter

Abstract excerpt

The gene encoding human tissue-type plasminogen activator (t-PA) is regulated in a cell-type-specific manner. Previous studies in non-endothelial cells have indicated that basal and phorbol ester mediated induction is controlled by a cAMP response element (CRE) referred to as the tPACRE, and an activating protein 2 (AP-2)-like site. The classification of the AP-2-like site was assigned on the basis of its...