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Article

Regulation of the Tissue Factor Promoter in Endothelial Cells

1 Feb 1995

Abstract excerpt

Tissue factor is up-regulated on endothelial cells and monocytes in response to cytokines and endotoxin and is the main trigger of the extrinsic pathway of the coagulation cascade. We have isolated the porcine tissue factor gene and studied the regulation of the promoter, which has not been investigated previously in endothelial cells. Comparison of the promoter sequences with the respective human and murine...

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Identifiers

PMID: 7876129
DOI: 10.1074/jbc.270.8.3849

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