Article
Expression and induction by IL-6 of the normal and variant genes for human plasminogen.
Biochemical and biophysical research communications - 3 Jan 1997
Kida M, Wakabayashi S, Ichinose A
Abstract excerpt
We examined the promoter activity of the gene for human plasminogen (PLG) employing its 1.1 kb fragment of the 5'-flanking region inserted in front of a reporter gene. Deletion analysis revealed that a region surrounding the transcription start site was essential for the PLG expression. Since the PLG gene has three sequences for the interleukin-6 (IL-6) responsive element, we examined the effect of IL-6 on the...
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