Article
The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.
Molecular and cellular biology - 1 Mar 1992
Leitman D C, Mackow E R, Williams T, Baxter J D, West B L
Abstract excerpt
Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors. To investigate the mechanism whereby...
Topics
- Base Sequence
- Cell Line
- DNA
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Protein Kinase C
- Tetradecanoylphorbol Acetate
- Transcription Factors
- Tumor Necrosis Factor-alpha