Article
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.
Science signaling - 10 Jan 2012
Biechele Travis L, Kulikauskas Rima M, Toroni Rachel A, Lucero Olivia M, Swift Reyna D, James Richard G, Robin Nick C, Dawson David W, Moon Randall T, Chien Andy J
Abstract excerpt
Because the Wnt/β-catenin signaling pathway is linked to melanoma pathogenesis and to patient survival, we conducted a kinome small interfering RNA (siRNA) screen in melanoma cells to expand our understanding of the kinases that regulate this pathway. We found that BRAF signaling, which is constitutively activated in many melanomas by the BRAF(V600E) mutation, inhibits Wnt/β-catenin signaling in human melanoma...
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