Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

1 Jun 1998

Abstract excerpt

BACKGROUND: The Wnt/Wingless signalling pathway plays an important role in both embryonic development and tumorigenesis. Beta-catenin and Axin are positive and negative effectors of the Wnt signalling pathway, respectively. RESULTS: We found that Axin interacts with beta-catenin and glycogen synthase kinase-3beta (GSK-3beta). Furthermore, the regulation of the G-protein signalling (RGS) domain of Axin is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Galectins and Cancer Biology
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9734785
DOI: 10.1046/j.1365-2443.1998.00198.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin levelPMID 9734785Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βSemantic proximity Read ↗

Wnt/beta-catenin signaling.Semantic proximity Read ↗

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.Semantic proximity Read ↗

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.Semantic proximity Read ↗

The genetic factors associated with Wnt signaling pathway in colorectal cancer.Semantic proximity Read ↗

Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal TumorigenesisSemantic proximity Read ↗

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer.Semantic proximity Read ↗

Diversity of axin in signaling pathways and its relation to colorectal cancer.Semantic proximity Read ↗

Axin1 Protects Colon Carcinogenesis by an Immune-Mediated EffectSemantic proximity Read ↗

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.Semantic proximity Read ↗

Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.