Synergy between T cell receptor beta gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis.

doi:10.1002/art.1780390609

Back to search

Article

Synergy between T cell receptor beta gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis.

Arthritis and rheumatism - 1 Jun 1996

Mu H, Charmley P, King M C, Criswell L A

Abstract excerpt

OBJECTIVE: To investigate the etiologic significance of germline polymorphisms in the T cell receptor beta variable region 6S7 (TCRBV6S7) gene segment and adjacent loci in susceptibility to rheumatoid arthritis (RA). METHODS: Ten TCRB allelic polymorphisms were analyzed from 3 groups of white wom...

Topics

Arthritis, Rheumatoid
Base Sequence
Disease Susceptibility
Female
Genotype
HLA-DR4 Antigen
Humans
Lupus Erythematosus, Systemic
Molecular Sequence Data
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.