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Article

V(beta)8(+) T cells protect from demyelinating disease in a viral model of multiple sclerosis.

International immunology - 1 Mar 2000

Drescher K M, Johnston S L, Hogancamp W, Nabozny G H, David C S, Rimm I J, Wettstein P J, Rodriguez M

Abstract excerpt

Previous studies illustrated the influence of T cell subsets on susceptibility or resistance to demyelination in the Theiler's murine encephalomyelitis virus (TMEV) model of multiple sclerosis. Genetic segregation analysis showed a correlation with disease phenotype in this model with particular V(beta) genes. In this study we investigated the contribution of specific V(beta) TCR to the pathogenesis of...

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Source

Identifiers

PMID: 10700462
DOI: 10.1093/intimm/12.3.271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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V(beta)8(+) T cells protect from demyelinating disease in a viral model of multiple sclerosis.PMID 10700462Read ↗

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Myelin basic protein-specific and TCR V beta 8.2-specific T-cell lines from TCR V beta 8.2 transgenic mice utilize the same V alpha and V beta genes: specificity associated with the V alpha CDR3-J alpha region.Semantic proximity Read ↗

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