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Article

P53 abnormalities and outcomes in colorectal cancer: a systematic review.

British journal of cancer - 14 Feb 2005

Munro A J, Lain S, Lane D P

Abstract excerpt

We performed a systematic review of studies that investigated the effect of abnormalities of the tumour suppressor gene p53 upon prognosis in patients with colorectal cancer. The methods used to assess p53 status were immunohistochemistry (IHC), indicating abnormal accumulation of p53, and sequence analysis, indicating presence of p53 mutations (mut). We identified 168 reports, with 241 comparisons of relevant...

Topics

Bias
Colorectal Neoplasms
Genes, p53
Humans
Immunohistochemistry
Mutation
Prognosis
Rectal Neoplasms
Regression Analysis
Survival Analysis
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15668707
DOI: 10.1038/sj.bjc.6602358
PMCID: PMC2362083

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