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Article

The Oncological Effect of Mutant p53 on the Metastatic Phenotype of Gastric Cancer Cells.

Anticancer research - 1 Nov 2023

Kitagawa Hiroshi, Hiraki Masatsugu, Namba Takushi, Baba Koichi, Miyake Shuusuke, Ito Kotaro, Tanaka Tomokazu, Noshiro Hirokazu

Abstract excerpt

BACKGROUND/AIM: P53 is the most frequently mutated tumor suppressor gene among all cancers. In human cancers, specific residues of p53 are mutated at a high frequency, and those mutations are known as hotspot mutations. Mutant p53 promotes tumor progression through the gain-of-function (GOF) mechanism. However, its biological characteristics, especially its metastatic potential, owing to different hotspot...

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PMID: 37909947
DOI: 10.21873/anticanres.16686

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