Article
A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.
Journal of human genetics - 1 Jan 2001
Ota N, Nakajima T, Nakazawa I, Suzuki T, Hosoi T, Orimo H, Inoue S, Shirai Y, Emi M
Abstract excerpt
Interleukin-6 (IL6) has come to be regarded as a potential osteoporotic factor because it has stimulatory effects on cells of the osteoclast lineage, and, thus, may play a role in the pathogenesis of bone loss associated with estrogen deficiency. We previously described association of the IL6 mic...
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