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Article

Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus.

The Journal of clinical endocrinology and metabolism - 1 Dec 1999

Takacs I, Koller D L, Peacock M, Christian J C, Hui S L, Conneally P M, Johnston C C, Foroud T, Econs M J

Abstract excerpt

A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. BMD is a complex trait that presumably is influenced by multiple genes. Insulin-like growth factor I (IGF-I) is an attractive candidate gene for osteoporosis susceptibility, because IGF-I has marked effects on bone cells and has been implicated in the pathogenesis of osteoporosis. The...

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PMID: 10599704
DOI: 10.1210/jcem.84.12.6179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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