Article
Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.
Journal of human genetics - 1 Jan 2003
Chung Hye Won, Seo Jeong-Sun, Hur Sung Eun, Kim Hyung Lae, Kim Jun Yeon, Jung Ji Hyun, Kim Lyoung Hyo, Park Byung Lae, Shin Hyoung Doo
Abstract excerpt
Interleukin-6 (IL6) has many roles essential to the regulation of the immune response, hematopoiesis, and bone resorption. Three single-nucleotide polymorphisms (SNP) in the IL6 promoter region were genotyped by the single-base extension method. The frequencies of each SNP were 0.002 ( IL6-597 G--> A), 0.27 ( IL6-572 G--> C), and 0.002 ( IL6-174 G--> C) in a Korean population ( n=1,082). IL6-597 G--> A and...
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