Article
Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos.
Mutation research - 22 Jun 2000
Ni Z, Liu Y, Keshava N, Zhou G, Whong W, Ong T
Abstract excerpt
Malignant mesothelioma is known to be associated with asbestos exposure. However, the mechanism of mesothelial carcinogenesis in relation to the activation of proto-oncogenes or inactivation of tumor suppressor genes remains unclear. In this study, the PCR-Primer Introduced Restriction Site (PCR-PIRS) assay was employed to examine mutations in the K-ras proto-oncogene in mesothelioma tissues from workers exposed...
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