k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.

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Article

k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.

Cancer research - 15 Sept 1999

Nelson H H, Christiani D C, Wiencke J K, Mark E J, Wain J C, Kelsey K T

Abstract excerpt

Environmental carcinogen exposure is requisite for the development of nearly all lung cancer, and it is well known that asbestos exposure interacts synergistically with tobacco smoke to induce lung cancer. However, the precise molecular lesions induced by asbestos are unknown. Furthermore, it is also unknown whether asbestos carcinogenesis proceeds in a fashion independent of or dependent upon the induction of...

Topics

Adenocarcinoma
Aged
Asbestos
Asbestosis
Carcinoma, Large Cell
Carcinoma, Squamous Cell
Exons
Female
Genes, ras
Humans
Lung Neoplasms
Male
Middle Aged
Mutation
Occupational Exposure
Polymerase Chain Reaction
Risk Factors
Smoking

Source

Open in PubMed

Identifiers

PMID: 10493509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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