Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.

doi:10.1093/carcin/15.2.257

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Article

Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.

Carcinogenesis - 1 Feb 1994

Nickell-Brady C, Hahn F F, Finch G L, Belinsky S A

Abstract excerpt

Beryllium (Be) metal and several of its analogues have been shown to be carcinogenic in rats. In addition, workers employed at Be processing plants have been shown to have a slight excess of lung cancer. In this study, a single inhalation exposure to Be metal produced a 64% incidence of lung tumo...

Topics

Animals
Base Sequence
Beryllium
DNA, Neoplasm
Genes, Neoplasm
Genes, p53
Genes, ras
Lung Neoplasms
Molecular Sequence Data
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Rats
Rats, Inbred F344

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