p53 and Kirsten-ras mutations in human mesothelioma cell lines.

Article

p53 and Kirsten-ras mutations in human mesothelioma cell lines.

Cancer research - 1 May 1992

Metcalf R A, Welsh J A, Bennett W P, Seddon M B, Lehman T A, Pelin K, Linnainmaa K, Tammilehto L, Mattson K, Gerwin B I

Abstract excerpt

Twenty cell lines from 17 individuals with malignant mesothelioma have been examined for p53 alterations by direct sequencing of genomic DNA, by evaluation of mRNA expression levels, and by immunocytochemical analysis of p53 protein expression in comparison with normal human pleural mesothelial c...

Topics

Animals
Codon
DNA Mutational Analysis
Genes, p53
Genes, ras
Humans
Mesothelioma
Mice
Mice, Nude
Mutation
RNA, Messenger
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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