Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.

doi:10.1289/ehp.93101s3189

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Article

Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.

Environmental health perspectives - 1 Oct 1993

Vainio H, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Hackman P, Partanen T

Abstract excerpt

To investigate the role of tobacco smoking and asbestos fibers in the etiology of human lung cancer, we examined the activating point mutations in the K-ras oncogene in DNA samples from 49 patients. Mutations were found more often in tissue from adenocarcinomas (12/21) than in tissue from tumors...

Topics

Adenocarcinoma
Aged
Asbestos
Female
Humans
Lung Neoplasms
Male
Middle Aged
Mutation
Smoking

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